Meliora Therapeutics is seeking a highly motivated Vice President (VP) of Drug Discovery to join their innovative team consisting of best-in-class scientists and founders.

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This role is responsible for driving Meliora pipeline programs across from early target discovery to IND. The successful VP of Drug Discovery will utilize the sophistication of the AnchorOmicsplatform to screen new chemical entities, design mechanism of action studies, and drive programs towards new clinical inflection points. This individual will collaborate with R&D functions and the Data Science team to build a robust pipeline of preclinical programs, recruit and train a nimble team, and establish a new headquarters with in-house labs that match the needs of the growing organization.  The successful candidate will have an established track record of progressing oncology programs from early-stage target validation to clinical trials.  

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What you'll do: 

• Lead the discovery research strategy to successfully bring programs from target identification and validation through lead optimization and to the clinic; be a key leader in prioritization of programs targeting a variety of cancer targets.
• Drive internal and external execution of research programs, including leveraging CROs for medicinal chemistry and synthetic chemistry.
• Refine therapeutic workstreams and candidate evaluation strategies across integrated teams from early-stage discovery to IND.
• Provide key insights and oversight of early target prioritization and disease/indication expansion.
• Establish roadmap for building capabilities to achieve balanced infrastructure leveraging both internal expertise and external resources.
• Promote strong scientific excellence and foster an open culture of ideation, innovation, and deep scientific rigor.
• Deliver and present key data packages and data-driven scientific updates to the organization that impact pipeline milestones and corporate objectives.
• Lead the expansion of the Drug Discovery team, recruiting key talent and managing, developing, and mentoring team members as they continue their growth as an agile organization.

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Background and skills we are looking for:

• Ph.D.  in chemistry or related field is required. 
• Minimum of 15 years of discovery research experience in pharma/biotechnology industry and 8 years of specific leadership and/or management experience; preference for individuals with a strong chemistry background.
• Deep domain expertise in oncology with an established track record of advancing programs to IND; intimately familiar with competitive landscape in targeted therapy drug development as well as latest scientific advances in target biology in the space. 
• Excellent oral, written, and strategic thinking skills with demonstrated ability to successfully lead the ideation and development of a plan and move to action.
• Ability to navigate, problem-solve, execute, and lead in a dynamic, fast-paced and evolving environment.
• Ability to provide leadership and role modeling for members of the team and other parts of the organization while also rolling up the sleeves to drive on the ground execution.  

What we offer:

• Highly competitive compensation with equity
• Medical, dental, and vision insurance plans
• The opportunity to have your career grow along with our company
• Work focused on developing cutting-edge technical methodologies to directly create meaningful positive impact on human health
• The freedom to develop your own methodologies and approaches in collaboration with our team to solve our most important challenges
• The opportunity to work with a world-class interdisciplinary team with expertise spanning numerous fields in biology, computer science, and machine learning. We learn from each other everyday and we’re excited to continue learning as we grow!
• Quarterly US based travel for on-site retreats

Meliora is seeking a proactive, detail oriented, organized, and passionate individual who wants to have an immense impact on building a next generation biotech company as Chief of Staff to the CEO.

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This position is a high leverage role with huge expansion opportunities and has an intimate view of building a biotech from the ground up. The role will report into the CEO and initial responsibilities will be spread across both key external and internal stakeholders, including helping drive and execute investor communications, business development partners, press, internal planning, hiring, and more. If you thrive in ambiguity, and desire to make an immense impact at a very early stage next-generation technology-focused biotech, this could be the perfect role for you.

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Background and skills we are looking for: 

• Ideal candidate has B.A., B.S., M.S. or Ph.D in a life sciences discipline as well as a background in strategic consulting, investment banking / private equity, or previous experience at an early stage startup is a plus
• Demonstrated track record of high performance, relentless execution in small, entrepreneurial environments
• Ability to influence stakeholders of all levels and drive appropriate prioritization of top strategic initiatives of the company 
• A tenacious approach to creating impact - ready to roll up the sleeves and do whatever it takes to move quickly and effectively 
• Strong data intuition - able to think critically, assess experimental data, and holistically review combinations of different scientific data sets in order to track and help drive key initiatives 
• Ability to be highly successful operating in a multidisciplinary environment and highly effective collaborating across functional teams is essential

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What you’ll do:

• Accelerate CEO day to day: Help CEO prepare and follow up after meetings.
• Build and oversee systems for critical business functions such as accounting, taxes, HR and other business functions 
• Evaluate and pursue strategic opportunities: Own special projects (e.g. evaluate a new business opportunity) that don’t fit into any existing organizational structure i.e. be ready to build systems 0 → 1 and create structure from of organizational ambiguity 
• Manage and execute strategic initiatives and communications across external partners (BD, investor relations) as well as internal partners (exec team) 
• Be flexible in taking on projects that will most meaningfully impact business bottom line
• Work with the leadership team and others to translate strategy into deliverables that can be measured and managed.
• Be a culture setter by embodying the company’s principles of truth-seeking, mutual respect, integrity, drive, and teamwork.

What we offer:

• Highly competitive compensation with equity
• Medical, dental, and vision insurance plans
• The opportunity to have your career grow along with our company
• Work focused on developing cutting-edge technical methodologies to directly create meaningful positive impact on human health
• The freedom to develop your own methodologies and approaches in collaboration with our team to solve our most important challenges
• The opportunity to work with a world-class interdisciplinary team with expertise spanning numerous fields in biology, computer science, and machine learning. We learn from each other everyday and we’re excited to continue learning as we grow!
• Quarterly US based travel for on-site retreats

Meliora is seeking talented machine learning engineers to play a key role in developing the core algorithmic engine of a next-generation biotechnology company.

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Machine learning team members play an important role in developing the core algorithmic engine of a next-generation biotechnology company, and so we are looking for people who delight in being multi-disciplinary, seek excellence at every turn, and have an unyielding desire to continuously learn and share knowledge. If this sounds like you, we would love to speak with you.

What you’ll do:

• Bring your technical skills to bear on a critical problem in cancer treatment that results in 97% of cancer drugs failing their clinical trials
• Develop, implement and validate novel, machine learning-driven methods of associating drugs and their properties with their true mechanism of action in cancer cells
• Lead the development of large-scale machine learning algorithm training and evaluation pipelines
• Grow, learn and contribute to cutting edge platform development that drives drug discovery.
• Be a culture-setter by embodying the company’s principles of truth-seeking, mutual respect, integrity, drive, and teamwork

Background and skills we are looking for:

• MS-level expertise in applied machine learning developed either through a formal degree or meaningful experience in performing similar work
• Expertise in the implementation of production-ready advanced machine learning algorithms using TensorFlow, PyTorch, or Jax
• Familiarity with and ability to develop large-scale machine learning systems and workflows including parallel training and evaluation pipelines
• A solid grasp of the fundamentals of machine learning science including broad capability in probability, statistics, machine learning, and programming
• Experience in solving deep technical challenges by helping to develop and validate novel methodologies
• Expertise in genomics or cheminformatics  isn’t necessary to start with, but you will need to be comfortable building an extensive cross-disciplinary background as you go
• Excellent communication skills to synthesize complex technical problems and solutions into content easily understandable by the scientific and leadership teams to facilitate critical decisions
• Ability to be highly successful operating in a multidisciplinary environment and a willingness to collaborate across functional teams is essential
• Bonus: experience working with biological or *omics datasets and pipelines

What we offer:

• Highly competitive compensation with equity
• Medical, dental, and vision insurance plans
• Remote work
• The opportunity to have your career grow along with our company
• Work focused on developing cutting-edge technical methodologies to directly create meaningful positive impact on human health
• The freedom to develop your own methodologies and approaches in collaboration with our team to solve our most important challenges
• The opportunity to work with a world-class interdisciplinary team with expertise spanning numerous fields in biology, computer science, and machine learning. We learn from each other everyday and we’re excited to continue learning as we grow!
• Quarterly US based travel for on-site retreats

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Meliora is seeking talented machine learning scientists to play a key role in developing the core algorithmic engine of a next-generation biotechnology company.

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Machine learning team members will play an important role in developing the core algorithmic engine of a next-generation biotechnology company, and so we are looking for people who delight in being multi-disciplinary, seek excellence at every turn, and have an unyielding desire to continuously learn and share knowledge. If this sounds like you, we would love to speak with you.

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What you’ll do:

• Bring your computational skills to bear on a critical problem in cancer treatment that results in 97% of cancer drugs failing their clinical trials
• Propose, develop, and validate novel, machine learning-driven methods of associating drugs and their properties with their true mechanism of action in cancer cells
• Advance the state-of-the-art in machine learning for biology by synthesizing techniques from disparate disciplines
• Contribute to publication efforts supporting Meliora's status as a leader in applied machine learning in cancer drug development
• Grow and learn. Deep expertise in genomics or cheminformatics isn’t necessary to start with, but you will need to be comfortable building an extensive cross-disciplinary background as we go.
• Be a culture-setter by embodying the company’s principles of truth-seeking, mutual respect, integrity, drive, and teamwork

Background and skills we are looking for:

• PhD-level expertise in applied machine learning developed either through a formal degree or meaningful experience in performing similar work
• Mastery of the fundamentals of machine learning science including broad capability in probability, statistics, machine learning, and programming
• Expertise in one or more areas of advanced machine learning, for example: graph neural networks, deep unsupervised learning, reinforcement learning, recommendation systems, causal inference, Bayesian global optimization, natural language processing, computer vision
• Practical experience applying these techniques to analyze and gain insight from interesting datasets with libraries such as TensorFlow, PyTorch, or Jax
• Experience in solving deep technical challenges by developing and validating novel methodologies
• Excellent communication skills to synthesize complex data problems and solutions into content easily understandable by the scientific and leadership teams to facilitate critical decisions
• Ability to be highly successful operating in a multidisciplinary environment and a willingness to collaborate across functional teams is essential
• Bonus: experience working with *omics datasets, and working knowledge of CRISPR and cancer biology

What we offer:

• Highly competitive compensation with equity
• Medical, dental, and vision insurance plans
• Remote work
• The opportunity to have your career grow along with our company
• Work focused on developing cutting-edge technical methodologies to directly create meaningful positive impact on human health
• The freedom to develop your own methodologies and approaches in collaboration with our team to solve our most important challenges
• The opportunity to work with a world-class interdisciplinary team with expertise spanning numerous fields in biology, computer science, and machine learning. We learn from each other everyday and we’re excited to continue learning as we grow!
• Quarterly US based travel for on-site retreats

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Meliora is seeking a talented and passionate computational biologist will work collaboratively with data science team members providing expertise in computational biology, playing an important role in developing the biological ideas underpinning the algorithmic engine of a next-generation biotechnology company. We are looking for people who delight in being multi-disciplinary, seek excellence at every turn, and have an unyielding desire to continuously learn and share knowledge.

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A key initial goal of Meliora Therapeutics’ computational engine is to develop a robust, multi-modal MOA atlas for cancer drugs. This atlas will consist of 21st century phenotypic “molecular fingerprints” of different mechanisms of action, and will serve as a reference library that can be used to characterize new molecules of interest. Our platform has already surfaced a number of interesting candidate drugs with promising laboratory validation and we are looking for world class talent to expand and deepen the capabilities of this advanced computational engine using the latest ML approaches, making an impact on cancer in the process.

Skills and Expertise required:

• PhD-level expertise in molecular biology or related fields such biochemistry, cell biology, oncology, structural biology, genetics, genomics, and others
• A solid understanding of one or more of the fundamentals of data science including probability, statistics, machine learning, and programming and a willingness to grow in each
• Practical experience applying computational biology techniques to analyze and gain insight from large datasets using Python or R
• Experience in developing novel biological hypotheses and using computational methods to test them
• Excellent communication skills to synthesize complex data problems and solutions into content easily understandable by the scientific and leadership teams to facilitate critical decisions
• Ability to be highly successful operating in a multidisciplinary environment and a willingness to collaborate across functional teams is essential
• Bonus: experience working directly with *omics datasets, and expertise in CRISPR and cancer biology

What you’ll do:

• Bring your computational skills and biological knowledge to bear on a critical problem in cancer treatment that contributes to the failure of 97% of cancer drugs in their clinical trials
• Propose, develop, and validate novel methods of associating drugs and their properties with their true mechanism of action in cancer cells
• Grow and learn. Deep expertise in advanced data science and machine learning isn’t necessary to start with, but you will need to be comfortable building an extensive cross-disciplinary background as we go.
• Be a culture-setter by embodying the company’s principles of truth-seeking, mutual respect, integrity, drive, and teamwork

What we offer:

• Highly competitive compensation with equity
• Medical, dental, and vision insurance plans
• Remote work
• The opportunity to have your career grow along with our company
• Work focused on developing cutting-edge technical methodologies to directly create meaningful positive impact on human health
• The freedom to develop your own methodologies and approaches in collaboration with our team to solve our most important challenges
• The opportunity to work with a world-class, remote-first, interdisciplinary team with expertise spanning numerous fields in biology, computer science, and machine learning. We learn from each other everyday and we’re excited to continue learning as we grow!
• Quarterly US based travel for on-site retreats

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We are looking for a talented and ambitious computational chemist who is passionate about making a difference in cancer care and loves working in the startup environment. Apply your expertise in Chemistry, Computational Chemistry, Cheminformatics or a related discipline in establishing the company’s capabilities in molecular design and drug development.

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You will play a significant role in developing the algorithmic engine of the company.  You will understand company goals and drive towards those goals, providing feedback about new opportunities and illuminating roadblocks when they occur. We value your unyielding scientific rigor and desire to continuously learn. The computational chemist will work collaboratively with a multi-disciplinary, international team, seeking excellence at every turn.

What you’ll do:

• Roll up your sleeves and bring your skills and experience in computational chemistry and drug development to bear on a critical problem in cancer drug discovery –  improving the success rate of cancer drugs brought to clinical trials.
• Apply the latest cheminformatics, computational chemistry, and/or molecular modeling strategies in order to build bridges linking cheminformatics, quantitative SAR modeling, and molecular modeling. This role features close interaction with interdisciplinary drug discovery project teams, including medicinal chemistry, discovery pharmacology and bioinformatics
• Spearhead small molecule library design while applying powerful analytic and visualization methods to explore structure-activity relationships
• Bring your curiosity and collegiality to our growing team.
• Be a culture setter by embodying the company’s principles of scientific and computational curiosity and rigor, mutual respect, personal integrity, drive, and collaboration.

Background and skills we are looking for:

• Ph.D, in Chemistry, Computational Chemistry, Cheminformatics or a related discipline
• Significant expertise modeling chemical and biology data in a drug discovery setting;
• Experience as a lead or manager of drug development program including expertise with principles of medicinal chemistry, ADME, PK and other key milestones required for clinical drug development
• Expertise in using molecular modeling and machine learning techniques to analyze and gain insight from biological or other data including cheminformatics libraries, such as TensorFlow, Keras, PyTorch, Pandas, Scikit-Learn, DeepChem, RDKit, or OEchem
• Excellent communication skills to synthesize complex technical problems and solutions into content easily understandable by the scientific and leadership teams to facilitate critical decisions
• Ability to be highly successful operating in a multidisciplinary environment and a willingness to collaborate across functional teams is essential

‍What we offer:

• Highly competitive compensation with equity
• Medical, dental, and vision insurance plans
• Remote work
• The opportunity to have your career grow along with our company
• Work focused on developing cutting-edge technical methodologies to directly create meaningful positive impact on human health
• The freedom to develop your own methodologies and approaches in collaboration with our team to solve our most important challenges
• The opportunity to work with a world-class interdisciplinary team with expertise spanning numerous fields in biology, computer science, and machine learning. We learn from each other everyday and we’re excited to continue learning as we grow!
• Quarterly US based travel for on-site retreats

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